Company Analysis

Alnylam Pharmaceuticals, Inc. (ALNY)

Nasdaq: ALNY · Pharmaceutical Preparations · Cambridge, MA · filing with the SEC since 2002
Grade6.8
◀ Past 7.0● Present 7.0▶ Future 6.3

The grade of Alnylam Pharmaceuticals, Inc.

Nine metrics read from its own filings, by tense
Headline grade
6.8/10
◀ Past7.030% of the headline
● Present7.040% of the headline
▶ Future6.330% of the headline

All three tenses have at least two readings, so the archetype blend applies as printed.

All nine metrics read as filed from the record.

◀ Past

What did they actually do?

7.0/1030% of the headline grade · 3 of 3 filed

Surviving crises

as filed
8.2/10

Has it survived what it has been through?

No warning events in its filings since 2017.

weight 33% of this tense · 82nd percentile among 497 sector filers · read for itself

From the record

Alnylam Pharmaceuticals, Inc.'s filings since 2017 show no warning events in the scan: no bankruptcy or receivership notice, no debt default notice, no exchange listing notice, no restatement warning, no auditor change, no material cyber incident and no late-report notice (its current reports).

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Track record

as filed
7.2/10

What has it actually done, year after year?

+62.4% a year over 10 filed years; profitable in 1 of 10.

weight 45% of this tense · 72nd percentile among 323 sector filers · read for its customers

From the record

Alnylam Pharmaceuticals, Inc.'s 10 filed years say what it did: revenue went from $47 million in fiscal 2016 to $3.7 billion in fiscal 2025, up 62.4% a year; it rose in 8 of 9 years; the deepest fall was 17% from fiscal 2017 to fiscal 2018; net income was positive in 1 of 10 of those years (its annual reports).

What it rests on

  • revenue growth over the filed span62.4%top 19% of its family
  • the share of years revenue rosetop 18% of its family
  • the share of filed years with a profittop 42% of its family
  • the deepest fall from a revenue peak16.7%top 30% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Shareholder treatment

as filed
4.8/10

How has it treated the people who own it?

Share count grew 3.4% a year. 0% of cash flow returned. Insiders: 268 sales, 2 purchases.

weight 22% of this tense · 48th percentile among 80 sector filers · read for its shareholders

From the record

Over the 3 fiscal years to 2025-12-31, Alnylam Pharmaceuticals, Inc.'s diluted share count grew about 3.4% a year, and dividends and buybacks returned about 0% of its operating cash flow over 3 years (its filed statements). Its officers and directors filed 268 sales (125 under scheduled 10b5-1 plans) and 2 purchases of their own stock on the open market in the year to 2026-11-12, buying about $543 thousand (their Form 4 filings).

What it rests on

  • the share count over the yearstop 23% of its family
  • cash returned against operating cash flowbottom 20% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

● Present

What are they doing right now?

7.0/1040% of the headline grade · 3 of 3 filed

Financial health

as filed
6.8/10

Is it financially healthy right now?

ROE 40%: 40¢ of profit per shareholder dollar. Leverage 84%: owes 84¢ per asset dollar.

weight 45% of this tense · 68th percentile among 473 sector filers · read for itself

From the record

Return on equity: in the fiscal year ended 2025-12-31, Alnylam Pharmaceuticals, Inc. earned about 40 cents of profit for every dollar of shareholders' money, and gross profitability: its products earned about 61 cents per dollar of everything the company owns (revenue less the cost of revenue). Leverage: it owed about 84 cents per dollar of assets, and net share issuance: its share count grew 5.5% over the year (the filed statements).

What it rests on

  • what it owes per dollar of assetsbottom 16% of its family
  • return on equitytop 3% of its family
  • gross profit against assetstop 10% of its family
  • the share count against the year beforetop 31% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Industry position

as filed
8.4/10

How strong is its position in its industry?

top 16% of 315 in its family; net margin 8.4%.

weight 33% of this tense · 84th percentile among 315 sector filers · read for its customers

From the record

Alnylam Pharmaceuticals, Inc.'s standing among 315 graded names in its industry family: revenue of $3.7 billion in fiscal 2025 ranks in the top 7% by size; a net margin of 8.4% ranks in the top 18%; revenue growth of 53% a year over the last 3 filed years ranks in the top 23% (its annual reports).

What it rests on

  • revenue against the family$3.71Btop 7% of its family
  • net margin8.4%top 18% of its family
  • three-year revenue growth53.0%top 23% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Leadership

as filed
5.4/10

What are the people in charge doing?

top 46% of 315 in its family for leadership; chief executive since 2022.

weight 22% of this tense · 54th percentile among 315 sector filers · read for its shareholders

From the record

Alnylam Pharmaceuticals, Inc.'s leadership, from its insiders' filings and its current reports: the chief executive on the record is Greenstreet, Yvonne (Chief Executive Officer, as filed), filing under that title since 2022-01-04, 4.9 years (bottom 47% of its family); the 18 officers and directors filing in the last fifteen months have been on the record a median of 6.2 years (top 37%); 8 officer or director changes were reported on Form 8-K since 2023-11-13, against the 18 people in charge now (top 47%; fewer changes for each person reads higher) (the Form 4 record, its Form 8-K reports). Years count from a person's first filing in the SEC's data sets, which begin in 2006, so each is a floor.

What it rests on

  • officer and director changes on Form 8-K, against the people in charge8 in three years among 18 peopletop 47% of its family
  • the median years the people in charge have filed6.2 yearstop 37% of its family
  • the chief executive's years on the record4.9 yearsbottom 47% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

▶ Future

What are they set up to do next?

6.3/1030% of the headline grade · 3 of 3 filed

Room to expand

as filed
6.1/10

How much room does it have to grow?

top 39% of 273 in its family for room to expand.

weight 45% of this tense · 61st percentile among 273 sector filers · read for itself

From the record

Alnylam Pharmaceuticals, Inc.'s room to grow, from the newest filed statements (fiscal 2025): cash of $1.7 billion against no long-term debt tagged leaves 33.4% of its assets as net cash, top 44% of its family; cash from operations less capital spending is 12.5% of revenue (top 19%); a gross margin of 81.8% (top 31%); research spending of 35.5% of revenue (bottom 36%) (its annual report).

What it rests on

  • cash less debt against assets33.4%top 44% of its family
  • cash from operations less capital spending against revenue12.5%top 19% of its family
  • gross margin81.8%top 31% of its family
  • research spending against revenue35.5%bottom 36% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Growth drivers

as filed
5.9/10

What could actually drive growth from here?

top 41% of 306 in its family for growth drivers.

weight 33% of this tense · 59th percentile among 306 sector filers · read for its customers

From the record

Alnylam Pharmaceuticals, Inc.'s growth drivers, from the filed years to fiscal 2025: revenue grew 53% a year over the last three filed years against 62.4% over all 10, slowing (bottom 35% of its family); the newest year grew 65.2% (top 21%); research spending grew 14.3% a year (top 32%); capital spending grew -6.6% a year (top 45%) (its annual reports). Alnylam Pharmaceuticals, Inc. reported 6 product lines in fiscal 2025: Amvuttra at $2.3 billion (62%), Collaborations at $553 million (15%), GIVLAARI at $308 million (8%), and 3 more; 5 of 6 grew against the year before (its annual report).

What it rests on

  • three-year growth against the whole span-9.5 points a yearbottom 35% of its family
  • the newest year's revenue growth65.2%top 21% of its family
  • three-year growth of research spending14.3%top 32% of its family
  • three-year growth of capital spending-6.6%top 45% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Expectations vs reality

as filed
7.4/10

Did its newest year beat what its own record pointed to?

top 26% of 233 in its family for expectations against reality.

weight 22% of this tense · 74th percentile among 233 sector filers · read for its shareholders

From the record

Alnylam Pharmaceuticals, Inc.'s newest year against its own record: revenue of $3.7 billion in fiscal 2025 came in 12.2% above the $3.3 billion its prior three years' pace pointed to (top 32% of its family); net income of $314 million against a prior three-year average of $617 million (top 10%); a net margin of 8.4% against -48.5% before (top 36%) (its annual reports).

What it rests on

  • revenue against the prior three years' pace12.2%top 32% of its family
  • net income against the prior three years' average+151%top 10% of its family
  • net margin against its prior average+56.9 pointstop 36% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

The grade is the company against its own industry, from its filings. It is not a view on the share price. How the grade is made

SI Assistanton ALNY · research, not advice