Company Analysis

Cyclerion Therapeutics, Inc. (CYCN)

Nasdaq: CYCN · Pharmaceutical Preparations · Cambridge, MA · filing with the SEC since 2018
Grade4.9
◀ Past 4.2● Present 5.3▶ Future 5.1
1 est.

The grade of Cyclerion Therapeutics, Inc.

Nine metrics read from its own filings, by tense
Headline grade
4.9/10
◀ Past4.225% of the headline
● Present5.335% of the headline
▶ Future5.140% of the headline

All three tenses have at least two readings, so the archetype blend applies as printed.

Of the nine metrics, 8 read as filed from the record and 1 is an SI estimate, each with its reasoning, its confidence and what would change it on its card.

◀ Past

What did they actually do?

4.2/1025% of the headline grade · 2 of 3 filed, 1 estimated

Surviving crises

as filed
5.0/10

Has it survived what it has been through?

2 warning events since 2018; the latest 2022-11-29.

weight 22% of this tense · 50th percentile among 497 sector filers · read for itself

From the record

Cyclerion Therapeutics, Inc.'s filings since 2018 show 2 warning events: a notice about its exchange listing (8-K item 3.01, 2 times, the latest 2022-11-29) (its current reports).

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Track record

as filed
2.5/10

What has it actually done, year after year?

-2% a year over 6 filed years; profitable in 0 of 6.

weight 45% of this tense · 25th percentile among 323 sector filers · read for its customers

From the record

Cyclerion Therapeutics, Inc.'s 6 filed years say what it did: revenue went from $2 million in fiscal 2020 to $2 million in fiscal 2025, down 2% a year; it rose in 2 of 4 years; the deepest fall was 100% from fiscal 2021 to fiscal 2023; net income was positive in 0 of 6 of those years (its annual reports).

What it rests on

  • revenue growth over the filed span-2.0%bottom 26% of its family
  • the share of years revenue rosebottom 36% of its family
  • the share of filed years with a profitbottom 27% of its family
  • the deepest fall from a revenue peak100.0%bottom 10% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Shareholder treatment

SI estimate
5.9/10

How has it treated the people who own it?

SI estimate 5.9/10, confidence 35 of 100 (one part).

weight 33% of this tense · 59th percentile among 464 sector filers · read for its shareholders

SI estimate Inferred, not read as filed

Why it is an estimate
Read from one part only, the share count over the years, which ranks in the top 41% of 464 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
What the record cannot read
Fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
How it was reasoned
one part: the share count over the years, the one part on file, ranked among 464 in its family.
Confidence
35 of 100
What would change it
A filing that carries the missing parts replaces this estimate with the filed reading.

From the record

SI estimate, not a filed reading: Cyclerion Therapeutics, Inc.'s shareholder treatment is put at 5.9 of 10 with a confidence of 35 of 100, because read from one part only, the share count over the years, which ranks in the top 41% of 464 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income. A filing that carries the missing parts replaces this estimate with the filed reading.

● Present

What are they doing right now?

5.3/1035% of the headline grade · 3 of 3 filed

Financial health

as filed
6.3/10

Is it financially healthy right now?

ROE -39%: lost 39¢ per shareholder dollar. Leverage 9%: owes 9¢ per asset dollar.

weight 45% of this tense · 63rd percentile among 473 sector filers · read for itself

From the record

Return on equity: in the fiscal year ended 2025-12-31, Cyclerion Therapeutics, Inc. lost about 39 cents for every dollar of shareholders' money. Leverage: it owed about 9 cents per dollar of assets, and net share issuance: its share count grew 26.3% over the year (the filed statements).

What it rests on

  • what it owes per dollar of assetstop 15% of its family
  • return on equitytop 42% of its family
  • the share count against the year beforebottom 44% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Industry position

as filed
5.4/10

How strong is its position in its industry?

top 46% of 315 in its family; net margin -170.1%.

weight 22% of this tense · 54th percentile among 315 sector filers · read for its customers

From the record

Cyclerion Therapeutics, Inc.'s standing among 315 graded names in its industry family: revenue of $2 million in fiscal 2025 ranks in the bottom 29% by size; a net margin of -170.1% ranks in the bottom 48%; revenue growth of 91.1% a year over the last 3 filed years ranks in the top 14% (its annual reports).

What it rests on

  • revenue against the family$2.1Mbottom 29% of its family
  • net margin-170.1%bottom 48% of its family
  • three-year revenue growth91.1%top 14% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Leadership

as filed
4.0/10

What are the people in charge doing?

bottom 40% of 315 in its family for leadership; chief executive since 2024.

weight 33% of this tense · 40th percentile among 315 sector filers · read for its shareholders

From the record

Cyclerion Therapeutics, Inc.'s leadership, from its insiders' filings and its current reports: the chief executive on the record is Graul, Regina Margaret (President and Chief Executive Officer, as filed), filing under that title since 2024-08-07, 2.3 years (bottom 25% of its family); most of the 12 officers and directors filing now have filed since the record of its people begins (2026-09-10), a floor of 2 months the record cannot see past, so that part is not read; 5 officer or director changes were reported on Form 8-K since 2023-11-13, against the 12 people in charge now (top 44%; fewer changes for each person reads higher) (the Form 4 record, its Form 8-K reports). Years count from a person's first filing in the SEC's data sets, which begin in 2006, so each is a floor.

What it rests on

  • officer and director changes on Form 8-K, against the people in charge5 in three years among 12 peopletop 44% of its family
  • the chief executive's years on the record2.3 yearsbottom 25% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

▶ Future

What are they set up to do next?

5.1/1040% of the headline grade · 3 of 3 filed

Room to expand

as filed
4.7/10

How much room does it have to grow?

bottom 47% of 273 in its family for room to expand.

weight 33% of this tense · 47th percentile among 273 sector filers · read for itself

From the record

Cyclerion Therapeutics, Inc.'s room to grow, from the newest filed statements (fiscal 2025): cash of $3 million against no long-term debt tagged leaves 32.4% of its assets as net cash, top 45% of its family; cash from operations less capital spending is -159.8% of revenue (bottom 45%); research spending of 46.2% of revenue (bottom 42%) (its annual report).

What it rests on

  • cash less debt against assets32.4%top 45% of its family
  • cash from operations less capital spending against revenue-159.8%bottom 45% of its family
  • research spending against revenue46.2%bottom 42% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Growth drivers

as filed
4.8/10

What could actually drive growth from here?

bottom 48% of 306 in its family for growth drivers.

weight 45% of this tense · 48th percentile among 306 sector filers · read for its customers

From the record

Cyclerion Therapeutics, Inc.'s growth drivers, from the filed years to fiscal 2025: revenue grew 91.1% a year over the last three filed years against -2% over all 6, speeding up (top 5% of its family); the newest year grew 3.7% (bottom 43%); research spending grew -45.7% a year (bottom 5%) (its annual reports). Cyclerion Therapeutics, Inc. reported 3 product lines in fiscal 2025: License Agreement at $1 million (48%), Purchase Agreement at $800 thousand (39%), Option Agreement at $274 thousand (13%); 1 of 2 grew against the year before (its annual report).

What it rests on

  • three-year growth against the whole span+93.1 points a yeartop 5% of its family
  • the newest year's revenue growth3.7%bottom 43% of its family
  • three-year growth of research spending-45.7%bottom 5% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Expectations vs reality

as filed
6.2/10

Did its newest year beat what its own record pointed to?

top 38% of 233 in its family for expectations against reality.

weight 22% of this tense · 62nd percentile among 233 sector filers · read for its shareholders

From the record

Cyclerion Therapeutics, Inc.'s newest year against its own record: revenue of $2 million in fiscal 2025 came in 60% below the $5 million its prior three years' pace pointed to (bottom 16% of its family); net income of $4 million against a prior three-year average of $17 million (top 22%); a net margin of a loss larger than its revenue against losses larger than its revenue before (top 8%) (its annual reports).

What it rests on

  • revenue against the prior three years' pace-60.0%bottom 16% of its family
  • net income against the prior three years' average+80%top 22% of its family
  • net margin against its prior averageup more than 100 pointstop 8% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

The grade is the company against its own industry, from its filings. It is not a view on the share price. How the grade is made

SI Assistanton CYCN · research, not advice