Patents
US patents through Dec 31, 2025 · PatentsView, from the USPTO’s Open Data Portal · read Oct 27, 2026
1,325 patents granted to the 4 names below, as the owner printed on each patent when it was granted. A later sale, a lapse or an expiry is not read, so this is what was granted to Ionis Pharmaceuticals, Inc.’s names, not what it holds today.
Patents granted
1,325
1,321 utility, 4 reissue, 1976 to Dec 31, 2025
Granted in 2025
18
Against 17 in 2024 and 25 in 2023
Applications published
1,230
42 of them in 2025
Names they are printed under
4
a former name, its own name
By yearGrantedApplications published
'11'12'13'14'15'16'17'18'19'20'21'22'23'24'25
Each pair is one calendar year. Applications are published about eighteen months after filing, so the newest years read low.
What they are aboutgrants since 2021
Pharmaceuticals79
Biotechnology30
Organic fine chemistry12
The main technology area of each patent, in the World Intellectual Property Organization’s 35 fields.
Under which name4 counted
Isis Pharmaceuticals, Inc. a former name
US, as the owner printed on each patent. 2 more under the same name are not counted (printed in CA, printed in SO)
1,050 granted
715 publishedIonis Pharmaceuticals, Inc. its own name
US, as the owner printed on each patent
275 granted
417 publishedIonis Pharmaceuticals, Inc. its own name
named as the applicant on its applications, in US
0 granted
85 publishedISIS PHARMACEUTICALS, INC. a former name
named as the applicant on its applications, in US. 1 more under the same name are not counted (printed in CA)
0 granted
13 published
Newest grantseach row opens the USPTO’s own copy
| Granted | Patent | Title | Field | Owner as printed |
|---|
| Dec 30, 2025 | 12,509,684 | Compositions and methods for modulating apolipoprotein C-III expression | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Dec 23, 2025 | 12,502,402 | Compounds and methods for modulating GFAP | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Dec 16, 2025 | 12,496,311 | Methods for safely reducing thrombopoietin | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Nov 25, 2025 | 12,480,126 | Modulation of dystrophia myotonica-protein kinase (DMPK) expression | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Sep 9, 2025 | 12,410,430 | Modulating apolipoprotein (A) expression | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Sep 9, 2025 | 12,409,188 | Modulators of HSD17B13 expression | Biotechnology | Ionis Pharmaceuticals, Inc. |
| Aug 12, 2025 | 12,384,814 | Compounds and methods for reducing app expression | Biotechnology | Ionis Pharmaceuticals, Inc. |
| Jul 8, 2025 | 12,350,285 | Compounds and methods for reducing ATXN3 expression | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Jul 1, 2025 | 12,343,357 | Compositions and methods for modulating MECP2 expression | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| May 13, 2025 | 12,297,431 | Modulation of huntingtin expression | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
Newest applications publishedan application is a clue, never a plan
| Published | Application | Title | Field | Owner as printed |
|---|
| Dec 11, 2025 | 2025/0376683 | Selective Antisense Compounds and Uses Thereof | Biotechnology | Ionis Pharmaceuticals, Inc. |
| Dec 4, 2025 | 2025/0368995 | Linkage Modified Oligomeric Compounds and Uses Thereof | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Dec 4, 2025 | 2025/0368993 | Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof | Biotechnology | Ionis Pharmaceuticals, Inc. |
| Nov 20, 2025 | 2025/0354147 | Antisense Compounds Targeted to CLN3 and Uses Thereof | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Nov 20, 2025 | 2025/0354135 | Modified Compounds and Uses Thereof | Biotechnology | Ionis Pharmaceuticals, Inc. |
| Nov 20, 2025 | 2025/0353873 | COMPOUNDS AND METHODS FOR MODULATING APOE EXPRESSION | Organic fine chemistry | Ionis Pharmaceuticals, Inc. |
| Nov 13, 2025 | 2025/0346907 | COMPOUNDS AND METHODS FOR REDUCING GLYCOGEN SYNTHASE 1 | Biotechnology | Ionis Pharmaceuticals, Inc. |
| Nov 13, 2025 | 2025/0346899 | CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
| Nov 13, 2025 | 2025/0346898 | Linkage Modified Oligomeric Compounds and Uses Thereof | Biotechnology | Ionis Pharmaceuticals, Inc. |
| Nov 6, 2025 | 2025/0340888 | COMPOUNDS AND METHODS FOR REDUCING PLN EXPRESSION | Pharmaceuticals | Ionis Pharmaceuticals, Inc. |
What it applied for, 2024 to 2025: Pharmaceuticals 58 · Biotechnology 34 · Organic fine chemistry 7 · Chemical engineering 2.
A patent is counted where the owner printed on it when it was granted carries the company’s own name, a former name, the name of a subsidiary its annual report lists, or its own name with a patent-holding phrase (Technology Licensing, Intellectual Property and the like), once the legal form, case and punctuation are set aside, and prints a country that name counts in. PatentsView’s data are published under the Creative Commons Attribution 4.0 licence. Source: PatentsView's granted patents and pre-grant publications, disambiguated, from the USPTO's Open Data Portal, through Dec 31, 2025, read Oct 27, 2026.