Karyopharm Therapeutics Inc. (KPTI)
Nasdaq: KPTI · Pharmaceutical Preparations · Newton, MA · filing with the SEC since 2010
Who owns Karyopharm Therapeutics Inc.
As filed with the SECHolders of 5% or more
7
RA Capital Management, L.P. holds 9.9% of Common Stock, $0.0001 par value per share, as its SCHEDULE 13G/A filed Aug 14, 2026 says.
Directors and officers
13
report now, of 33 people on the record since 2013. Their holdings as a group are not read here.
Institutions as a whole
n/a
The record does not read the share held by managers that file Form 13F, so none is printed and no split of the rest is estimated. What it holds is the 7 named at left.
Holders of 5% or moreshare of the class, as filed
RA Capital Management, L.P.
SCHEDULE 13G/A · filed Aug 14, 2026 · Common Stock, $0.0001 par value per share · 9.9% in Apr 2, 2026
Affinity Asset Advisors, LLC
SCHEDULE 13G/A · filed May 14, 2026 · Common Stock, $0.0001 par value per share · 8.6% in Jan 29, 2026
Adage Capital Management, L.P.
SCHEDULE 13G/A · filed Aug 12, 2026 · Common Stock, par value $0.0001 per share · 8.08% in May 13, 2026
T. Rowe Price Investment Management, Inc.
SCHEDULE 13G/A · filed Jun 5, 2026 · COMMON STOCK · 11.8% in Feb 17, 2026
Goldman Sachs Group Inc.
SCHEDULE 13G/A · filed Aug 11, 2026 · Common Stock, par value $0.0001 per share · 5.1% in May 12, 2026
Integrated Core Strategies (US) LLC
SCHEDULE 13G · filed Sep 4, 2026 · Common Stock, par value $0.0001 per share · 2.3% in Apr 13, 2026
Blackrock, Inc.
SCHEDULE 13G · filed Jul 28, 2026 · Common Stock
J. Wood Capital Advisors LLC
SCHEDULE 13G/A · filed Nov 3, 2025 · Common Stock, $0.0001 par value · reported falling below 5%
Highbridge Capital Management, LLC
SCHEDULE 13G/A · filed Nov 14, 2025 · Common Stock, par value $0.0001 per share · reported falling below 5%
JPMorgan Chase & Co.
SCHEDULE 13G/A · filed Oct 17, 2025 · Common Stock, $0.0001 par value · reported falling below 5%, from 5.2% in Jul 16, 2025
The Vanguard Group
SCHEDULE 13G/A · filed Oct 30, 2025 · Common Stock · reported falling below 5%
Anders Hove
SCHEDULE 13G/A · filed Oct 8, 2026 · Common Stock, $0.0001 Par Value · reported falling below 5%, from 5.7% in Sep 25, 2026
Opaleye Management Inc.
SCHEDULE 13G/A · filed May 11, 2026 · Common Stock, $0.0001 par value per share · reported falling below 5%, from 9.48% in Oct 17, 2025
Commodore Capital LP
SCHEDULE 13G/A · filed Aug 14, 2026 · Common Stock, $0.0001 par value · reported falling below 5%, from 9.9% in Apr 2, 2026
Ikarian Capital, LLC
SCHEDULE 13G · filed May 15, 2026 · Common Stock, par value $0.0001 per share · reported falling below 5%
What KPTI reports owning in othersstakes of 5% or more, and other ties
Other ties the annual report names
HealthCare Royalty Partners IV LP
An entity · legal entity · owns, named in the 10-K filed Feb 13, 2026
2 subsidiaries in 2 countries, from the list filed with the 10-K filed Feb 13, 2026.
Insider tradesForm 4
21sales
0purchases
0sales on a scheduled plan
7people selling
$400,000sold, in dollars
$0bought, in dollars
Open-market trades on Form 4 from Oct 19, 2025 to Oct 19, 2026. A scheduled plan is a selling program set in advance under SEC rule 10b5-1. The trades are listed as filed and do not feed the grade.
By calendar yearSoldBought
2026 runs to Oct 19, 2026. Dollars as filed, summed by the transaction date.
People who traded in the window7 of 38 on the roster
| Person | Role as filed | Sales | Sold | On a plan | Buys | Bought |
|---|---|---|---|---|---|---|
| Paulson Richard A. | President and CEO | 2 | $100,000 | 0 | 0 | $0 |
| Poulton Stuart | EVP, Chief Development Officer | 4 | $100,000 | 0 | 0 | $0 |
| Rangwala Reshma | EVP & Chief Medical Officer | 3 | $100,000 | 0 | 0 | $0 |
| Macomber Lori | EVP, CFO & Treasurer | 1 | $0 | 0 | 0 | $0 |
| Abate Kristin | Chief Accounting Officer | 7 | $0 | 0 | 0 | $0 |
| Cheng Sohanya Roshan | EVP & Chief Commercial Officer | 2 | $0 | 0 | 0 | $0 |
| Mano Michael | EVP, CLO&Secretary | 2 | $0 | 0 | 0 | $0 |