Prelude Therapeutics Incorporated (PRLD)

Nasdaq: PRLD · Pharmaceutical Preparations · Wilmington, DE · filing with the SEC since 2016

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Grade5.0

◀ Past 4.8● Present 5.1▶ Future 5.1

4 est.

Overview Business Financials Grade Forecast Sentiment Ownership People Filings Patents Chart

Who owns Prelude Therapeutics Incorporated

As filed with the SEC

Holders of 5% or more

Orbimed Advisors LLC holds 16% of COMMON STOCK, as its SCHEDULE 13D/A filed Apr 23, 2026 says.

Directors and officers

report now, of 30 people on the record since 2020. Their holdings as a group are not read here.

Institutions as a whole

n/a

The record does not read the share held by managers that file Form 13F, so none is printed and no split of the rest is estimated. What it holds is the 6 named at left.

Holders of 5% or moreshare of the class, as filed

Orbimed Advisors LLC

SCHEDULE 13D/A · filed Apr 23, 2026 · COMMON STOCK

16%

Baker Bros. Advisors LP

SCHEDULE 13D/A · filed Apr 22, 2026 · Common Stock, $0.0001 par value per share · 23.5% in Jun 13, 2025

15.5%

Vaddi Krishna

SCHEDULE 13G/A · filed Feb 13, 2026 · Common Stock, par value $0.0001 per share · 13.8% in May 15, 2025

13.2%

RA Capital Management, L.P.

SCHEDULE 13G · filed Apr 28, 2026 · Common Stock, $0.0001 par value per share

9.9%

Incyte Corp.

SCHEDULE 13G · filed Nov 7, 2025 · Common Stock, par value $0.0001 per share

9.9%

Soleus Capital Management, L.P.

SCHEDULE 13G · filed Jul 8, 2026 · Common Stock, par value $0.0001 per share

5.2%

Deerfield Mgmt, L.P.

SCHEDULE 13G/A · filed Feb 13, 2025 · Common Stock · reported falling below 5%

under 5%

What PRLD reports owning in othersstakes of 5% or more, and other ties

Prelude Therapeutics Incorporated reports no stake in another company in the record.

Insider tradesForm 4

0sales

4purchases

0sales on a scheduled plan

0people selling

$0sold, in dollars

$25.0Mbought, in dollars

Open-market trades on Form 4 from Sep 30, 2025 to Sep 30, 2026. A scheduled plan is a selling program set in advance under SEC rule 10b5-1. The trades are listed as filed and do not feed the grade.

By calendar yearSoldBought

20212223242526

2026 runs to Sep 30, 2026. Dollars as filed, summed by the transaction date.

People who traded in the window2 of 34 on the roster

Person	Role as filed	Sales	Sold	On a plan	Buys	Bought
Bonita David P	director	0	$0	0	2	$12.5M
Orbimed Genesis Gp LLC	director	0	$0	0	2	$12.5M

SI Assistanton PRLD · research, not advice