Company Analysis

Spyre Therapeutics, Inc. (SYRE)

Nasdaq: SYRE · Pharmaceutical Preparations · Waltham, MA · filing with the SEC since 2015
Grade5.2
◀ Past 2.7● Present 6.0▶ Future 6.2
5 est.

Filings

491 filings since 2017 beside 256 insider forms · Large accelerated filer · read from EDGAR on Nov 13, 2026
Due nextLarge accelerated filer
10-K Annual report for the fiscal year ending Dec 31, 2026Large accelerated filers have 60 days after the fiscal year ends. by Mar 1, 2027
10-Q Quarterly report for the quarter ending Mar 31, 2027Large accelerated filers have 40 days after the quarter ends; quarter ends are taken to the month end. by May 10, 2027

A deadline is the latest date the SEC's rules allow for its filer category. It is not a forecast of the day the company files. Last time, the results release (8-K item 2.02) came 34 days after the quarter ended. The proxy statement was last filed Apr 10, 2026.

Filings a yearinsider forms included
5556626911011652100
20192020202120222023202420252026

2026 counts to Nov 13, 2026.

Officer or director change (8-K item 5.02): 4 times in the last 36 months, the newest May 29, 2026.Auditor change (8-K item 4.01): 1 time in the last 36 months, the newest Mar 6, 2025.Warning not to rely on past financial statements (8-K item 4.02): 1 time in the last 36 months, the newest Nov 18, 2024.Listing warning from its exchange (8-K item 3.01): 1 time in the last 36 months, the newest Jan 18, 2024.SEC letters: 23 in the last 36 months, the newest Feb 25, 2026.
Insider forms 256

Insider forms (3, 4, 5 and 144) are counted each year but not listed here; the people and their trades are on the Ownership tab.

FiledFormWhat it is, in plain wordsPeriodAsk
Nov 3, 2026 8-K items 2.02, 9.01 Results released · Current report
Nov 3, 2026 10-Q Quarterly report Sep 30, 2026
Oct 9, 2026 SCHEDULE 13D/A Activist holder update, amended
Oct 7, 2026 8-K items 1.01, 9.01 Major agreement signed · Current report Oct 5, 2026
Oct 6, 2026 424B5 Shelf offering
Oct 5, 2026 424B5 Shelf offering
Oct 1, 2026 SCHEDULE 13G Large holder notice
Sep 8, 2026 8-K items 7.01, 8.01, 9.01 Investor disclosure (Regulation FD); Other event · Current report
Aug 25, 2026 8-K items 7.01, 8.01, 9.01 Investor disclosure (Regulation FD); Other event · Current report
Aug 14, 2026 SCHEDULE 13G/A Large holder update, amended
Aug 14, 2026 SCHEDULE 13G/A Large holder update, amended
Aug 4, 2026 8-K items 2.02, 9.01 Results released · Current report
Aug 4, 2026 10-Q Quarterly report Jun 30, 2026
Jun 26, 2026 S-3ASR Shelf registration
Jun 23, 2026 SCHEDULE 13D/A Activist holder update, amended
Jun 15, 2026 8-K items 7.01, 8.01, 9.01 Investor disclosure (Regulation FD); Other event · Current report
Jun 1, 2026 8-K items 8.01, 9.01 Other event · Current report May 29, 2026
May 29, 2026 8-K items 5.02, 5.07, 9.01 Officer or director change; Shareholder vote · Current report May 27, 2026
May 5, 2026 8-K items 2.02, 9.01 Results released · Current report
May 5, 2026 10-Q Quarterly report Mar 31, 2026
Apr 22, 2026 SCHEDULE 13G Large holder notice
Apr 20, 2026 SCHEDULE 13D/A Activist holder update, amended
Apr 16, 2026 8-K items 1.01, 9.01 Major agreement signed · Current report Apr 14, 2026
Apr 16, 2026 424B5 Shelf offering
Apr 13, 2026 424B5 Shelf offering
Apr 13, 2026 8-K items 2.02, 8.01 Results released; Other event · Current report
Apr 13, 2026 8-K items 7.01, 8.01, 9.01 Investor disclosure (Regulation FD); Other event · Current report
Apr 10, 2026 ARS Annual report to shareholders Dec 31, 2025
Apr 10, 2026 DEFA14A Extra proxy material
Apr 10, 2026 DEF 14A Proxy statement May 27, 2026
Mar 27, 2026 SCHEDULE 13G/A Large holder update, amended
Mar 4, 2026 EFFECT Registration effective
Feb 27, 2026 EFFECT Registration effective
Feb 27, 2026 POS AM Registration amended after taking effect
Feb 25, 2026 CORRESP Reply to the SEC
Feb 25, 2026 UPLOAD SEC comment letter
Feb 19, 2026 S-8 Employee stock plan registration
Feb 19, 2026 8-K items 2.02, 9.01 Results released · Current report
Feb 19, 2026 10-K Annual report Dec 31, 2025
Feb 19, 2026 S-3 Shelf registration
40 of 491 shown

Every row opens the filing on EDGAR. The plain words are the site's own for each form and each 8-K item; the complete history, insider forms included, is on EDGAR.

SI Assistanton SYRE · research, not advice