Company Analysis

Taysha Gene Therapies, Inc. (TSHA)

Nasdaq: TSHA · Biological Products, (No Diagnostic Substances) · Dallas, TX · filing with the SEC since 2020
Grade5.0
◀ Past 4.3● Present 5.6▶ Future 5.0
1 est.

The grade of Taysha Gene Therapies, Inc.

Nine metrics read from its own filings, by tense
Headline grade
5.0/10
◀ Past4.325% of the headline
● Present5.635% of the headline
▶ Future5.040% of the headline

All three tenses have at least two readings, so the archetype blend applies as printed.

Of the nine metrics, 8 read as filed from the record and 1 is an SI estimate, each with its reasoning, its confidence and what would change it on its card.

◀ Past

What did they actually do?

4.3/1025% of the headline grade · 2 of 3 filed, 1 estimated

Surviving crises

as filed
4.8/10

Has it survived what it has been through?

2 warning events since 2020; the latest 2023-08-04.

weight 22% of this tense · 48th percentile among 159 sector filers · read for itself

From the record

Taysha Gene Therapies, Inc.'s filings since 2020 show 2 warning events: a notice about its exchange listing (8-K item 3.01, 2 times, the latest 2023-08-04) (its current reports).

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Track record

as filed
6.1/10

What has it actually done, year after year?

+57.5% a year over 4 filed years; profitable in 0 of 4.

weight 45% of this tense · 61st percentile among 102 sector filers · read for its customers

From the record

Taysha Gene Therapies, Inc.'s 4 filed years say what it did: revenue went from $3 million in fiscal 2022 to $10 million in fiscal 2025, up 57.5% a year; it rose in 2 of 3 years; the deepest fall was 46% from fiscal 2023 to fiscal 2024; net income was positive in 0 of 4 of those years (its annual reports).

What it rests on

  • revenue growth over the filed span57.5%top 18% of its family
  • the share of years revenue rosetop 36% of its family
  • the share of filed years with a profitbottom 31% of its family
  • the deepest fall from a revenue peak46.1%top 33% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Shareholder treatment

SI estimate
1.5/10

How has it treated the people who own it?

SI estimate 1.5/10, confidence 35 of 100 (one part).

weight 33% of this tense · 15th percentile among 146 sector filers · read for its shareholders

SI estimate Inferred, not read as filed

Why it is an estimate
Read from one part only, the share count over the years, which ranks in the bottom 15% of 146 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
What the record cannot read
Fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
How it was reasoned
one part: the share count over the years, the one part on file, ranked among 146 in its family.
Confidence
35 of 100
What would change it
A filing that carries the missing parts replaces this estimate with the filed reading.

From the record

SI estimate, not a filed reading: Taysha Gene Therapies, Inc.'s shareholder treatment is put at 1.5 of 10 with a confidence of 35 of 100, because read from one part only, the share count over the years, which ranks in the bottom 15% of 146 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income. A filing that carries the missing parts replaces this estimate with the filed reading.

● Present

What are they doing right now?

5.6/1035% of the headline grade · 3 of 3 filed

Financial health

as filed
5.2/10

Is it financially healthy right now?

ROE -44%: lost 44¢ per shareholder dollar. Leverage 28%: owes 28¢ per asset dollar.

weight 45% of this tense · 52nd percentile among 147 sector filers · read for itself

From the record

Return on equity: in the fiscal year ended 2025-12-31, Taysha Gene Therapies, Inc. lost about 44 cents for every dollar of shareholders' money. Leverage: it owed about 28 cents per dollar of assets, and net share issuance: its share count grew 27.8% over the year (the filed statements).

What it rests on

  • what it owes per dollar of assetstop 38% of its family
  • return on equitytop 41% of its family
  • the share count against the year beforebottom 35% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Industry position

as filed
5.0/10

How strong is its position in its industry?

top 50% of 102 in its family; net margin -1115.3%.

weight 22% of this tense · 50th percentile among 102 sector filers · read for its customers

From the record

Taysha Gene Therapies, Inc.'s standing among 102 graded names in its industry family: revenue of $10 million in fiscal 2025 ranks in the bottom 37% by size; a net margin of -1115.3% ranks in the bottom 32%; revenue growth of 57.5% a year over the last 3 filed years ranks in the top 17% (its annual reports).

What it rests on

  • revenue against the family$9.8Mbottom 37% of its family
  • net margin-1115.3%bottom 32% of its family
  • three-year revenue growth57.5%top 17% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Leadership

as filed
6.7/10

What are the people in charge doing?

top 33% of 110 in its family for leadership; chief executive since 2023.

weight 33% of this tense · 67th percentile among 110 sector filers · read for its shareholders

From the record

Taysha Gene Therapies, Inc.'s leadership, from its insiders' filings and its current reports: the chief executive on the record is Nolan, Sean P. (Chief Executive Officer, as filed), filing under that title since 2023-01-04, 3.9 years (bottom 40% of its family); the 7 officers and directors filing in the last fifteen months have been on the record a median of 6.1 years (top 31%); 1 officer or director change was reported on Form 8-K since 2023-11-13, against the 7 people in charge now (top 10%; fewer changes for each person reads higher) (the Form 4 record, its Form 8-K reports). Years count from a person's first filing in the SEC's data sets, which begin in 2006, so each is a floor.

What it rests on

  • officer and director changes on Form 8-K, against the people in charge1 in three years among 7 peopletop 10% of its family
  • the median years the people in charge have filed6.1 yearstop 31% of its family
  • the chief executive's years on the record3.9 yearsbottom 40% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

▶ Future

What are they set up to do next?

5.0/1040% of the headline grade · 3 of 3 filed

Room to expand

as filed
6.1/10

How much room does it have to grow?

top 39% of 92 in its family for room to expand.

weight 33% of this tense · 61st percentile among 92 sector filers · read for itself

From the record

Taysha Gene Therapies, Inc.'s room to grow, from the newest filed statements (fiscal 2025): cash of $320 million against debt of $50 million leaves 78.5% of its assets as net cash, top 15% of its family; cash from operations less capital spending is -960.1% of revenue (bottom 28%); research spending of 884.1% of revenue (top 28%) (its annual report).

What it rests on

  • cash less debt against assets78.5%top 15% of its family
  • cash from operations less capital spending against revenue-960.1%bottom 28% of its family
  • research spending against revenue884.1%top 28% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Growth drivers

as filed
4.2/10

What could actually drive growth from here?

bottom 41% of 100 in its family for growth drivers.

weight 45% of this tense · 41st percentile among 100 sector filers · read for its customers

From the record

Taysha Gene Therapies, Inc.'s growth drivers, from the filed years to fiscal 2025: revenue grew 57.5% a year over the last three filed years against 57.5% over all 4, speeding up (top 36% of its family); the newest year grew 17.3% (top 48%); research spending grew -1.8% a year (bottom 41%); capital spending grew -67% a year (bottom 9%) (its annual reports). Taysha Gene Therapies, Inc. tags no split of its revenue by line in the annual report on file, so growth by line cannot be read here; research and capital spending are on the trend.

What it rests on

  • three-year growth against the whole span+0.0 points a yeartop 36% of its family
  • the newest year's revenue growth17.3%top 48% of its family
  • three-year growth of research spending-1.8%bottom 41% of its family
  • three-year growth of capital spending-67.0%bottom 9% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Expectations vs reality

as filed
5.1/10

Did its newest year beat what its own record pointed to?

top 49% of 72 in its family for expectations against reality.

weight 22% of this tense · 51st percentile among 72 sector filers · read for its shareholders

From the record

Taysha Gene Therapies, Inc.'s newest year against its own record: revenue of $10 million in fiscal 2025 came in 35.7% below the $15 million its prior three years' pace pointed to (bottom 19% of its family); net income of $109 million against a prior three-year average of $122 million (bottom 49%); a net margin of a loss larger than its revenue against losses larger than its revenue before (top 15%) (its annual reports).

What it rests on

  • revenue against the prior three years' pace-35.7%bottom 19% of its family
  • net income against the prior three years' average+11%bottom 49% of its family
  • net margin against its prior averageup more than 100 pointstop 15% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

The grade is the company against its own industry, from its filings. It is not a view on the share price. How the grade is made

SI Assistanton TSHA · research, not advice