Company Analysis

OPKO Health, Inc. (OPK)

Nasdaq: OPK · Pharmaceutical Preparations · Miami, FL · filing with the SEC since 1996
Grade5.2
◀ Past 5.3● Present 6.2▶ Future 3.9
1 est.

The grade of OPKO Health, Inc.

Nine metrics read from its own filings, by tense
Headline grade
5.2/10
◀ Past5.330% of the headline
● Present6.240% of the headline
▶ Future3.930% of the headline

All three tenses have at least two readings, so the archetype blend applies as printed.

Of the nine metrics, 8 read as filed from the record and 1 is an SI estimate, each with its reasoning, its confidence and what would change it on its card.

◀ Past

What did they actually do?

5.3/1030% of the headline grade · 2 of 3 filed, 1 estimated

Surviving crises

as filed
5.6/10

Has it survived what it has been through?

1 warning event since 2017; the latest 2024-03-01.

weight 33% of this tense · 56th percentile among 497 sector filers · read for itself

From the record

OPKO Health, Inc.'s filings since 2017 show 1 warning event: a late-report notice (Form NT 10-K or NT 10-Q, the latest 2024-03-01) (its current reports).

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Track record

as filed
3.6/10

What has it actually done, year after year?

-6.6% a year over 10 filed years; profitable in 1 of 10.

weight 45% of this tense · 36th percentile among 323 sector filers · read for its customers

From the record

OPKO Health, Inc.'s 10 filed years say what it did: revenue went from $1.1 billion in fiscal 2016 to $607 million in fiscal 2025, down 6.6% a year; it rose in 3 of 9 years; the deepest fall was 66% from fiscal 2021 to fiscal 2025; net income was positive in 1 of 10 of those years (its annual reports).

What it rests on

  • revenue growth over the filed span-6.6%bottom 21% of its family
  • the share of years revenue rosebottom 17% of its family
  • the share of filed years with a profittop 42% of its family
  • the deepest fall from a revenue peak65.8%bottom 47% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Shareholder treatment

SI estimate
8.2/10

How has it treated the people who own it?

SI estimate 8.2/10, confidence 35 of 100 (one part).

weight 22% of this tense · 82nd percentile among 464 sector filers · read for its shareholders

SI estimate Inferred, not read as filed

Why it is an estimate
Read from one part only, the share count over the years, which ranks in the top 18% of 464 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
What the record cannot read
Fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
How it was reasoned
one part: the share count over the years, the one part on file, ranked among 464 in its family.
Confidence
35 of 100
What would change it
A filing that carries the missing parts replaces this estimate with the filed reading.

From the record

SI estimate, not a filed reading: OPKO Health, Inc.'s shareholder treatment is put at 8.2 of 10 with a confidence of 35 of 100, because read from one part only, the share count over the years, which ranks in the top 18% of 464 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income. A filing that carries the missing parts replaces this estimate with the filed reading.

● Present

What are they doing right now?

6.2/1040% of the headline grade · 3 of 3 filed

Financial health

as filed
5.6/10

Is it financially healthy right now?

ROE -18%: lost 18¢ per shareholder dollar. Leverage 34%: owes 34¢ per asset dollar.

weight 45% of this tense · 56th percentile among 473 sector filers · read for itself

From the record

Return on equity: in the fiscal year ended 2025-12-31, OPKO Health, Inc. lost about 18 cents for every dollar of shareholders' money, and gross profitability: its products earned about 11 cents per dollar of everything the company owns. Leverage: it owed about 34 cents per dollar of assets, and net share issuance: its share count grew 8.2% over the year (the filed statements).

What it rests on

  • what it owes per dollar of assetstop 50% of its family
  • return on equitytop 26% of its family
  • gross profit against assetsbottom 33% of its family
  • the share count against the year beforetop 35% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Industry position

as filed
5.6/10

How strong is its position in its industry?

top 44% of 315 in its family; net margin -37.2%.

weight 33% of this tense · 56th percentile among 315 sector filers · read for its customers

From the record

OPKO Health, Inc.'s standing among 315 graded names in its industry family: revenue of $607 million in fiscal 2025 ranks in the top 17% by size; a net margin of -37.2% ranks in the top 38%; revenue growth of -15.5% a year over the last 3 filed years ranks in the bottom 23% (its annual reports).

What it rests on

  • revenue against the family$607Mtop 17% of its family
  • net margin-37.2%top 38% of its family
  • three-year revenue growth-15.5%bottom 23% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Leadership

as filed
8.3/10

What are the people in charge doing?

top 17% of 315 in its family for leadership; chief executive since 2007.

weight 22% of this tense · 83rd percentile among 315 sector filers · read for its shareholders

From the record

OPKO Health, Inc.'s leadership, from its insiders' filings and its current reports: the chief executive on the record is Frost, Phillip Md Et Al (CEO & Chairman, as filed), filing under that title since 2007-03-30, 19.6 years (top 3% of its family); the 9 officers and directors filing in the last fifteen months have been on the record a median of 19.6 years (top 1%); 4 officer or director changes were reported on Form 8-K since 2023-11-13, against the 9 people in charge now (top 47%; fewer changes for each person reads higher) (the Form 4 record, its Form 8-K reports). Years count from a person's first filing in the SEC's data sets, which begin in 2006, so each is a floor.

What it rests on

  • officer and director changes on Form 8-K, against the people in charge4 in three years among 9 peopletop 47% of its family
  • the median years the people in charge have filed19.6 yearstop 1% of its family
  • the chief executive's years on the record19.6 yearstop 3% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

▶ Future

What are they set up to do next?

3.9/1030% of the headline grade · 3 of 3 filed

Room to expand

as filed
3.5/10

How much room does it have to grow?

bottom 35% of 273 in its family for room to expand.

weight 45% of this tense · 35th percentile among 273 sector filers · read for itself

From the record

OPKO Health, Inc.'s room to grow, from the newest filed statements (fiscal 2025): cash of $364 million against debt of $2 million leaves 18.7% of its assets as net cash, bottom 37% of its family; cash from operations less capital spending is -31.4% of revenue (top 41%); a gross margin of 33.9% (bottom 18%); research spending of 20.4% of revenue (bottom 25%) (its annual report).

What it rests on

  • cash less debt against assets18.7%bottom 37% of its family
  • cash from operations less capital spending against revenue-31.4%top 41% of its family
  • gross margin33.9%bottom 18% of its family
  • research spending against revenue20.4%bottom 25% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Growth drivers

as filed
4.6/10

What could actually drive growth from here?

bottom 46% of 306 in its family for growth drivers.

weight 33% of this tense · 46th percentile among 306 sector filers · read for its customers

From the record

OPKO Health, Inc.'s growth drivers, from the filed years to fiscal 2025: revenue grew -15.5% a year over the last three filed years against -6.6% over all 10, slowing (bottom 37% of its family); the newest year grew -14.9% (bottom 28%); research spending grew 18.8% a year (top 26%); capital spending grew -20.6% a year (bottom 43%) (its annual reports). OPKO Health, Inc. reported 3 product lines in fiscal 2025: Service at $370 million (61%), Product at $157 million (26%), Transfer of Intellectual Property and Other at $80 million (13%); 2 of 3 grew against the year before (its annual report).

What it rests on

  • three-year growth against the whole span-8.9 points a yearbottom 37% of its family
  • the newest year's revenue growth-14.9%bottom 28% of its family
  • three-year growth of research spending18.8%top 26% of its family
  • three-year growth of capital spending-20.6%bottom 43% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Expectations vs reality

as filed
3.9/10

Did its newest year beat what its own record pointed to?

bottom 39% of 233 in its family for expectations against reality.

weight 22% of this tense · 39th percentile among 233 sector filers · read for its shareholders

From the record

OPKO Health, Inc.'s newest year against its own record: revenue of $607 million in fiscal 2025 came in 1% above the $601 million its prior three years' pace pointed to (top 43% of its family); net income of $226 million against a prior three-year average of $190 million (bottom 34%); a net margin of -37.2% against -20.7% before (bottom 27%) (its annual reports).

What it rests on

  • revenue against the prior three years' pace1.0%top 43% of its family
  • net income against the prior three years' average-19%bottom 34% of its family
  • net margin against its prior average-16.5 pointsbottom 27% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

The grade is the company against its own industry, from its filings. It is not a view on the share price. How the grade is made

SI Assistanton OPK · research, not advice