Company Analysis

Vertex Pharmaceuticals Incorporated (VRTX)

Nasdaq: VRTX · Pharmaceutical Preparations · Boston, MA · filing with the SEC since 1995
Grade7.0
◀ Past 7.3● Present 7.6▶ Future 5.9

The grade of Vertex Pharmaceuticals Incorporated

Nine metrics read from its own filings, by tense
Headline grade
7.0/10
◀ Past7.330% of the headline
● Present7.640% of the headline
▶ Future5.930% of the headline

All three tenses have at least two readings, so the archetype blend applies as printed.

All nine metrics read as filed from the record.

◀ Past

What did they actually do?

7.3/1030% of the headline grade · 3 of 3 filed

Surviving crises

as filed
5.0/10

Has it survived what it has been through?

1 warning event since 2017; the latest 2019-09-17.

weight 33% of this tense · 50th percentile among 497 sector filers · read for itself

From the record

Vertex Pharmaceuticals Incorporated's filings since 2017 show 1 warning event: a debt default or acceleration notice (8-K item 2.04, the latest 2019-09-17) (its current reports).

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Track record

as filed
8.4/10

What has it actually done, year after year?

+24.2% a year over 10 filed years; profitable in 8 of 10.

weight 45% of this tense · 84th percentile among 323 sector filers · read for its customers

From the record

Vertex Pharmaceuticals Incorporated's 10 filed years say what it did: revenue went from $1.7 billion in fiscal 2016 to $12 billion in fiscal 2025, up 24.2% a year; it rose in 9 of 9 years; it never fell from a peak; net income was positive in 8 of 10 of those years (its annual reports).

What it rests on

  • revenue growth over the filed span24.2%top 36% of its family
  • the share of years revenue rosetop 8% of its family
  • the share of filed years with a profittop 8% of its family
  • the deepest fall from a revenue peak0.0%top 10% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Shareholder treatment

as filed
8.7/10

How has it treated the people who own it?

Share count shrank 0.1% a year. 54% of cash flow returned. Insiders: 94 sales, 0 purchases.

weight 22% of this tense · 87th percentile among 80 sector filers · read for its shareholders

From the record

Over the 3 fiscal years to 2025-12-31, Vertex Pharmaceuticals Incorporated's diluted share count shrank about 0.1% a year, and dividends and buybacks returned about 54% of its operating cash flow over 3 years (its filed statements). Its officers and directors filed 94 sales (94 under scheduled 10b5-1 plans) and 0 purchases of their own stock on the open market in the year to 2026-11-10 (their Form 4 filings).

What it rests on

  • the share count over the yearstop 10% of its family
  • cash returned against operating cash flowtop 17% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

● Present

What are they doing right now?

7.6/1040% of the headline grade · 3 of 3 filed

Financial health

as filed
7.8/10

Is it financially healthy right now?

ROE 21%: 21¢ of profit per shareholder dollar. Leverage 27%: owes 27¢ per asset dollar.

weight 45% of this tense · 78th percentile among 473 sector filers · read for itself

From the record

Return on equity: in the fiscal year ended 2025-12-31, Vertex Pharmaceuticals Incorporated earned about 21 cents of profit for every dollar of shareholders' money, and gross profitability: its products earned about 40 cents per dollar of everything the company owns (revenue less the cost of revenue). Leverage: it owed about 27 cents per dollar of assets, and net share issuance: its share count was unchanged over the year (the filed statements).

What it rests on

  • what it owes per dollar of assetstop 43% of its family
  • return on equitytop 7% of its family
  • gross profit against assetstop 29% of its family
  • the share count against the year beforetop 9% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Industry position

as filed
8.0/10

How strong is its position in its industry?

top 20% of 315 in its family; net margin 32.9%.

weight 33% of this tense · 80th percentile among 315 sector filers · read for its customers

From the record

Vertex Pharmaceuticals Incorporated's standing among 315 graded names in its industry family: revenue of $12 billion in fiscal 2025 ranks in the top 4% by size; a net margin of 32.9% ranks in the top 8%; revenue growth of 10.3% a year over the last 3 filed years ranks in the top 47% (its annual reports).

What it rests on

  • revenue against the family$12.00Btop 4% of its family
  • net margin32.9%top 8% of its family
  • three-year revenue growth10.3%top 47% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Leadership

as filed
6.7/10

What are the people in charge doing?

top 33% of 315 in its family for leadership; chief executive since 2020.

weight 22% of this tense · 67th percentile among 315 sector filers · read for its shareholders

From the record

Vertex Pharmaceuticals Incorporated's leadership, from its insiders' filings and its current reports: the chief executive on the record is Kewalramani, Reshma (CEO & President, as filed), filing under that title since 2020-05-08, 6.5 years (top 32% of its family); the 24 officers and directors filing in the last fifteen months have been on the record a median of 6.1 years (top 39%); 7 officer or director changes were reported on Form 8-K since 2023-11-13, against the 24 people in charge now (top 29%; fewer changes for each person reads higher) (the Form 4 record, its Form 8-K reports). Years count from a person's first filing in the SEC's data sets, which begin in 2006, so each is a floor.

What it rests on

  • officer and director changes on Form 8-K, against the people in charge7 in three years among 24 peopletop 29% of its family
  • the median years the people in charge have filed6.1 yearstop 39% of its family
  • the chief executive's years on the record6.5 yearstop 32% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

▶ Future

What are they set up to do next?

5.9/1030% of the headline grade · 3 of 3 filed

Room to expand

as filed
6.0/10

How much room does it have to grow?

top 40% of 273 in its family for room to expand.

weight 45% of this tense · 60th percentile among 273 sector filers · read for itself

From the record

Vertex Pharmaceuticals Incorporated's room to grow, from the newest filed statements (fiscal 2025): cash of $5.1 billion against no long-term debt tagged leaves 19.8% of its assets as net cash, bottom 39% of its family; cash from operations less capital spending is 26.6% of revenue (top 9%); a gross margin of 86.2% (top 25%); research spending of 32.6% of revenue (bottom 35%) (its annual report).

What it rests on

  • cash less debt against assets19.8%bottom 39% of its family
  • cash from operations less capital spending against revenue26.6%top 9% of its family
  • gross margin86.2%top 25% of its family
  • research spending against revenue32.6%bottom 35% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Growth drivers

as filed
5.8/10

What could actually drive growth from here?

top 42% of 306 in its family for growth drivers.

weight 33% of this tense · 58th percentile among 306 sector filers · read for its customers

From the record

Vertex Pharmaceuticals Incorporated's growth drivers, from the filed years to fiscal 2025: revenue grew 10.3% a year over the last three filed years against 24.2% over all 10, slowing (bottom 29% of its family); the newest year grew 8.9% (top 48%); research spending grew 15.5% a year (top 30%); capital spending grew 28.8% a year (top 20%) (its annual reports). Vertex Pharmaceuticals Incorporated reported 6 product lines in fiscal 2025: TRIKAFTAKAFTRIO at $10 billion (85%), ALYFTREK at $838 million (7%), Manufactured Product Other at $820 million (7%), and 3 more; 3 of 3 grew against the year before (its annual report).

What it rests on

  • three-year growth against the whole span-13.9 points a yearbottom 29% of its family
  • the newest year's revenue growth8.9%top 48% of its family
  • three-year growth of research spending15.5%top 30% of its family
  • three-year growth of capital spending28.8%top 20% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Expectations vs reality

as filed
6.0/10

Did its newest year beat what its own record pointed to?

top 40% of 233 in its family for expectations against reality.

weight 22% of this tense · 60th percentile among 233 sector filers · read for its shareholders

From the record

Vertex Pharmaceuticals Incorporated's newest year against its own record: revenue of $12 billion in fiscal 2025 came in 2% below the $12 billion its prior three years' pace pointed to (bottom 50% of its family); net income of $4.0 billion against a prior three-year average of $2.1 billion (top 20%); a net margin of 32.9% against 23% before (bottom 49%) (its annual reports).

What it rests on

  • revenue against the prior three years' pace-2.0%top 50% of its family
  • net income against the prior three years' average+85%top 20% of its family
  • net margin against its prior average+9.9 pointsbottom 49% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

The grade is the company against its own industry, from its filings. It is not a view on the share price. How the grade is made

SI Assistanton VRTX · research, not advice