Company Analysis

Xilio Therapeutics, Inc. (XLO)

Nasdaq: XLO · Pharmaceutical Preparations · Waltham, MA · filing with the SEC since 2021
Grade4.7
◀ Past 4.1● Present 4.1▶ Future 5.9
4 est.

The grade of Xilio Therapeutics, Inc.

Nine metrics read from its own filings, by tense
Headline grade
4.7/10
◀ Past4.130% of the headline
● Present4.140% of the headline
▶ Future5.930% of the headline

All three tenses have at least two readings, so the archetype blend applies as printed.

Of the nine metrics, 5 read as filed from the record and 4 are SI estimates, each with its reasoning, its confidence and what would change it on its card.

◀ Past

What did they actually do?

4.1/1030% of the headline grade · 1 of 3 filed, 2 estimated

Surviving crises

as filed
3.5/10

Has it survived what it has been through?

5 warning events since 2021; the latest 2025-10-03.

weight 33% of this tense · 35th percentile among 497 sector filers · read for itself

From the record

Xilio Therapeutics, Inc.'s filings since 2021 show 5 warning events: a notice about its exchange listing (8-K item 3.01, 5 times, the latest 2025-10-03) (its current reports).

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Track record

SI estimate
5.1/10

What has it actually done, year after year?

SI estimate 5.1/10, confidence 20 of 100 (family median).

weight 45% of this tense · 50th percentile among 324 sector filers · read for its customers

SI estimate Inferred, not read as filed

Why it is an estimate
Fewer than three filed years of revenue on file, so the desk assumes the typical reading of its industry family, the median of 324 members with one.
What the record cannot read
Fewer than three filed years of revenue on file.
How it was reasoned
family median, 324 readings behind it.
Confidence
20 of 100
What would change it
Its next annual report on file with the inputs replaces this estimate with the filed reading.

From the record

SI estimate, not a filed reading: Xilio Therapeutics, Inc.'s track record is put at 5.1 of 10 with a confidence of 20 of 100, because fewer than three filed years of revenue on file, so the desk assumes the typical reading of its industry family, the median of 324 members with one. Its next annual report on file with the inputs replaces this estimate with the filed reading.

Shareholder treatment

SI estimate
2.8/10

How has it treated the people who own it?

SI estimate 2.8/10, confidence 35 of 100 (one part).

weight 22% of this tense · 28th percentile among 464 sector filers · read for its shareholders

SI estimate Inferred, not read as filed

Why it is an estimate
Read from one part only, the share count over the years, which ranks in the bottom 28% of 464 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
What the record cannot read
Fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
How it was reasoned
one part: the share count over the years, the one part on file, ranked among 464 in its family.
Confidence
35 of 100
What would change it
A filing that carries the missing parts replaces this estimate with the filed reading.

From the record

SI estimate, not a filed reading: Xilio Therapeutics, Inc.'s shareholder treatment is put at 2.8 of 10 with a confidence of 35 of 100, because read from one part only, the share count over the years, which ranks in the bottom 28% of 464 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income. A filing that carries the missing parts replaces this estimate with the filed reading.

● Present

What are they doing right now?

4.1/1040% of the headline grade · 3 of 3 filed

Financial health

as filed
2.4/10

Is it financially healthy right now?

ROE -99%: lost 99¢ per shareholder dollar. Leverage 77%: owes 77¢ per asset dollar.

weight 45% of this tense · 24th percentile among 473 sector filers · read for itself

From the record

Return on equity: in the fiscal year ended 2025-12-31, Xilio Therapeutics, Inc. lost about 99 cents for every dollar of shareholders' money. Leverage: it owed about 77 cents per dollar of assets, and net share issuance: its share count grew 118.7% over the year (the filed statements).

What it rests on

  • what it owes per dollar of assetsbottom 18% of its family
  • return on equitybottom 32% of its family
  • the share count against the year beforebottom 22% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Industry position

as filed
6.9/10

How strong is its position in its industry?

top 31% of 315 in its family; net margin -80.1%.

weight 33% of this tense · 69th percentile among 315 sector filers · read for its customers

From the record

Xilio Therapeutics, Inc.'s standing among 315 graded names in its industry family: revenue of $44 million in fiscal 2025 ranks in the top 46% by size; a net margin of -80.1% ranks in the top 44%; revenue growth of 590.8% a year over the last 1 filed years ranks in the top 3% (its annual reports).

What it rests on

  • revenue against the family$43.8Mtop 46% of its family
  • net margin-80.1%top 44% of its family
  • three-year revenue growth590.8%top 3% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Leadership

as filed
3.6/10

What are the people in charge doing?

bottom 36% of 315 in its family for leadership; chief executive since 2021.

weight 22% of this tense · 36th percentile among 315 sector filers · read for its shareholders

From the record

Xilio Therapeutics, Inc.'s leadership, from its insiders' filings and its current reports: the chief executive on the record is Russo, Rene (PRESIDENT AND CEO, as filed), filing under that title since 2021-10-21, 5.1 years (bottom 48% of its family); the 13 officers and directors filing in the last fifteen months have been on the record a median of 3.3 years (bottom 18%); 7 officer or director changes were reported on Form 8-K since 2023-11-13, against the 13 people in charge now (bottom 42%; fewer changes for each person reads higher) (the Form 4 record, its Form 8-K reports). Years count from a person's first filing in the SEC's data sets, which begin in 2006, so each is a floor.

What it rests on

  • officer and director changes on Form 8-K, against the people in charge7 in three years among 13 peoplebottom 42% of its family
  • the median years the people in charge have filed3.3 yearsbottom 18% of its family
  • the chief executive's years on the record5.1 yearsbottom 48% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

▶ Future

What are they set up to do next?

5.9/1030% of the headline grade · 1 of 3 filed, 2 estimated

Room to expand

as filed
7.0/10

How much room does it have to grow?

top 30% of 273 in its family for room to expand.

weight 45% of this tense · 70th percentile among 273 sector filers · read for itself

From the record

Xilio Therapeutics, Inc.'s room to grow, from the newest filed statements (fiscal 2025): cash of $139 million against no long-term debt tagged leaves 90.1% of its assets as net cash, top 10% of its family; cash from operations less capital spending is -12.6% of revenue (top 34%); research spending of 128% of revenue (top 47%) (its annual report).

What it rests on

  • cash less debt against assets90.1%top 10% of its family
  • cash from operations less capital spending against revenue-12.6%top 34% of its family
  • research spending against revenue128.0%top 47% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Growth drivers

SI estimate
5.0/10

What could actually drive growth from here?

SI estimate 5.0/10, confidence 20 of 100 (family median).

weight 33% of this tense · 50th percentile among 307 sector filers · read for its customers

SI estimate Inferred, not read as filed

Why it is an estimate
The record does not carry three filed years of revenue and two of the four parts: acceleration, the newest year's growth, the growth of research and of capital spending, so the desk assumes the typical reading of its industry family, the median of 307 members with one.
What the record cannot read
The record does not carry three filed years of revenue and two of the four parts: acceleration, the newest year's growth, the growth of research and of capital spending.
How it was reasoned
family median, 307 readings behind it.
Confidence
20 of 100
What would change it
Its next annual report on file with the inputs replaces this estimate with the filed reading.

From the record

SI estimate, not a filed reading: Xilio Therapeutics, Inc.'s growth drivers is put at 5.0 of 10 with a confidence of 20 of 100, because the record does not carry three filed years of revenue and two of the four parts: acceleration, the newest year's growth, the growth of research and of capital spending, so the desk assumes the typical reading of its industry family, the median of 307 members with one. Its next annual report on file with the inputs replaces this estimate with the filed reading.

Expectations vs reality

SI estimate
5.3/10

Did its newest year beat what its own record pointed to?

SI estimate 5.3/10, confidence 20 of 100 (family median).

weight 22% of this tense · 50th percentile among 234 sector filers · read for its shareholders

SI estimate Inferred, not read as filed

Why it is an estimate
The record does not carry four filed years of revenue and two of the three parts: revenue against the prior pace, earnings against the prior average, the margin change, so the desk assumes the typical reading of its industry family, the median of 234 members with one.
What the record cannot read
The record does not carry four filed years of revenue and two of the three parts: revenue against the prior pace, earnings against the prior average, the margin change.
How it was reasoned
family median, 234 readings behind it.
Confidence
20 of 100
What would change it
Its next annual report on file with the inputs replaces this estimate with the filed reading.

From the record

SI estimate, not a filed reading: Xilio Therapeutics, Inc.'s expectations vs reality is put at 5.3 of 10 with a confidence of 20 of 100, because the record does not carry four filed years of revenue and two of the three parts: revenue against the prior pace, earnings against the prior average, the margin change, so the desk assumes the typical reading of its industry family, the median of 234 members with one. Its next annual report on file with the inputs replaces this estimate with the filed reading.

The grade is the company against its own industry, from its filings. It is not a view on the share price. How the grade is made

SI Assistanton XLO · research, not advice