Company Analysis

Zymeworks Inc. (ZYME)

Nasdaq: ZYME · Pharmaceutical Preparations · Middletown, DE · filing with the SEC since 2022
Grade5.1
◀ Past 5.8● Present 5.1▶ Future 4.4
1 est.

The grade of Zymeworks Inc.

Nine metrics read from its own filings, by tense
Headline grade
5.1/10
◀ Past5.830% of the headline
● Present5.140% of the headline
▶ Future4.430% of the headline

All three tenses have at least two readings, so the archetype blend applies as printed.

Of the nine metrics, 8 read as filed from the record and 1 is an SI estimate, each with its reasoning, its confidence and what would change it on its card.

◀ Past

What did they actually do?

5.8/1030% of the headline grade · 2 of 3 filed, 1 estimated

Surviving crises

as filed
5.0/10

Has it survived what it has been through?

1 warning event since 2022; the latest 2022-12-05.

weight 33% of this tense · 50th percentile among 497 sector filers · read for itself

From the record

Zymeworks Inc.'s filings since 2022 show 1 warning event: a notice about its exchange listing (8-K item 3.01, the latest 2022-12-05) (its current reports).

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Track record

as filed
5.5/10

What has it actually done, year after year?

+22.2% a year over 6 filed years; profitable in 1 of 6.

weight 45% of this tense · 55th percentile among 323 sector filers · read for its customers

From the record

Zymeworks Inc.'s 6 filed years say what it did: revenue went from $39 million in fiscal 2020 to $106 million in fiscal 2025, up 22.2% a year; it rose in 3 of 5 years; the deepest fall was 82% from fiscal 2022 to fiscal 2023; net income was positive in 1 of 6 of those years (its annual reports).

What it rests on

  • revenue growth over the filed span22.2%top 38% of its family
  • the share of years revenue rosetop 50% of its family
  • the share of filed years with a profittop 30% of its family
  • the deepest fall from a revenue peak81.6%bottom 39% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Shareholder treatment

SI estimate
7.4/10

How has it treated the people who own it?

SI estimate 7.4/10, confidence 35 of 100 (one part).

weight 22% of this tense · 74th percentile among 464 sector filers · read for its shareholders

SI estimate Inferred, not read as filed

Why it is an estimate
Read from one part only, the share count over the years, which ranks in the top 26% of 464 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
What the record cannot read
Fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income.
How it was reasoned
one part: the share count over the years, the one part on file, ranked among 464 in its family.
Confidence
35 of 100
What would change it
A filing that carries the missing parts replaces this estimate with the filed reading.

From the record

SI estimate, not a filed reading: Zymeworks Inc.'s shareholder treatment is put at 7.4 of 10 with a confidence of 35 of 100, because read from one part only, the share count over the years, which ranks in the top 26% of 464 in its family; fewer than two of the parts can be read: the share count over the years, and the cash returned against a positive operating cash flow or net income. A filing that carries the missing parts replaces this estimate with the filed reading.

● Present

What are they doing right now?

5.1/1040% of the headline grade · 3 of 3 filed

Financial health

as filed
7.5/10

Is it financially healthy right now?

ROE -30%: lost 30¢ per shareholder dollar. Leverage 23%: owes 23¢ per asset dollar.

weight 45% of this tense · 75th percentile among 473 sector filers · read for itself

From the record

Return on equity: in the fiscal year ended 2025-12-31, Zymeworks Inc. lost about 30 cents for every dollar of shareholders' money. Leverage: it owed about 23 cents per dollar of assets, and net share issuance: its share count shrank 0.6% over the year (the filed statements).

What it rests on

  • what it owes per dollar of assetstop 36% of its family
  • return on equitytop 34% of its family
  • the share count against the year beforetop 6% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Industry position

as filed
4.5/10

How strong is its position in its industry?

bottom 45% of 315 in its family; net margin -76.6%.

weight 33% of this tense · 45th percentile among 315 sector filers · read for its customers

From the record

Zymeworks Inc.'s standing among 315 graded names in its industry family: revenue of $106 million in fiscal 2025 ranks in the top 35% by size; a net margin of -76.6% ranks in the top 44%; revenue growth of -36.4% a year over the last 3 filed years ranks in the bottom 13% (its annual reports).

What it rests on

  • revenue against the family$106Mtop 35% of its family
  • net margin-76.6%top 44% of its family
  • three-year revenue growth-36.4%bottom 13% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Leadership

as filed
1.3/10

What are the people in charge doing?

bottom 13% of 315 in its family for leadership; chief executive since 2022.

weight 22% of this tense · 13th percentile among 315 sector filers · read for its shareholders

From the record

Zymeworks Inc.'s leadership, from its insiders' filings and its current reports: the chief executive on the record is Galbraith, Kenneth (Chair & CEO, as filed), filing under that title since the record of its people begins (2022-10-17), so the years before are not on the record and this part is not read; the 17 officers and directors filing in the last fifteen months have been on the record a median of 2.2 years (bottom 8%); 14 officer or director changes were reported on Form 8-K since 2023-11-13, against the 17 people in charge now (bottom 19%; fewer changes for each person reads higher) (the Form 4 record, its Form 8-K reports). Years count from a person's first filing in the SEC's data sets, which begin in 2006, so each is a floor.

What it rests on

  • officer and director changes on Form 8-K, against the people in charge14 in three years among 17 peoplebottom 19% of its family
  • the median years the people in charge have filed2.2 yearsbottom 8% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

▶ Future

What are they set up to do next?

4.4/1030% of the headline grade · 3 of 3 filed

Room to expand

as filed
4.7/10

How much room does it have to grow?

bottom 47% of 273 in its family for room to expand.

weight 45% of this tense · 47th percentile among 273 sector filers · read for itself

From the record

Zymeworks Inc.'s room to grow, from the newest filed statements (fiscal 2025): cash of $41 million against no long-term debt tagged leaves 11.9% of its assets as net cash, bottom 29% of its family; cash from operations less capital spending is -32.6% of revenue (top 42%); research spending of 129.3% of revenue (top 47%) (its annual report).

What it rests on

  • cash less debt against assets11.9%bottom 29% of its family
  • cash from operations less capital spending against revenue-32.6%top 42% of its family
  • research spending against revenue129.3%top 47% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Growth drivers

as filed
3.3/10

What could actually drive growth from here?

bottom 33% of 306 in its family for growth drivers.

weight 33% of this tense · 33rd percentile among 306 sector filers · read for its customers

From the record

Zymeworks Inc.'s growth drivers, from the filed years to fiscal 2025: revenue grew -36.4% a year over the last three filed years against 22.2% over all 6, slowing (bottom 10% of its family); the newest year grew 38.9% (top 30%); research spending grew -13.1% a year (bottom 26%); capital spending grew -42.8% a year (bottom 27%) (its annual reports). Zymeworks Inc. tags no split of its revenue by line in the annual report on file, so growth by line cannot be read here; research and capital spending are on the trend.

What it rests on

  • three-year growth against the whole span-58.6 points a yearbottom 10% of its family
  • the newest year's revenue growth38.9%top 30% of its family
  • three-year growth of research spending-13.1%bottom 26% of its family
  • three-year growth of capital spending-42.8%bottom 27% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

Expectations vs reality

as filed
5.3/10

Did its newest year beat what its own record pointed to?

top 47% of 233 in its family for expectations against reality.

weight 22% of this tense · 53rd percentile among 233 sector filers · read for its shareholders

From the record

Zymeworks Inc.'s newest year against its own record: revenue of $106 million in fiscal 2025 came in 222.7% above the $33 million its prior three years' pace pointed to (top 11% of its family); net income of $81 million against a prior three-year average of $39 million (bottom 14%); a net margin of -76.6% against -95.6% before (top 45%) (its annual reports).

What it rests on

  • revenue against the prior three years' pace222.7%top 11% of its family
  • net income against the prior three years' average-108%bottom 14% of its family
  • net margin against its prior average+19.0 pointstop 45% of its family

A production reading, recomputed from the filings on every data build, read from EDGAR Nov 13, 2026.

The grade is the company against its own industry, from its filings. It is not a view on the share price. How the grade is made

SI Assistanton ZYME · research, not advice